6-Methylquinoline → 6-(Bromomethyl)quinoline
반응식
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2.C1C(=O)N([Br:19])C(=O)C1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:19][CH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2참가 물질
5
실험 절차
To a solution of 6-methylquinoline (2.15 g, 15.0 mmol) in CCl4 (30 mL) was added NBS (2.92 g, 16.5 mmol) and benzoyl peroxide (BP, 0.36 g, 1.5 mmol) at room temperature. The mixture was heated at reflux for 2 hours. After cooling, the mixture was evaporated under vacuum to give a yellow solid, which was extracted with Petroleum Ether (30 mL×5). The extracts were concentrated under vacuum to give crude 6-bromomethylquinoline (1.8 g), which was used directly in the next step.
후처리
- temperatureThe mixture was heated
- temperatureat reflux for 2 hours
- temperatureAfter cooling
- customthe mixture was evaporated under vacuum
- customto give a yellow solid, which
- extractionwas extracted with Petroleum Ether (30 mL×5)
- concentrationThe extracts were concentrated under vacuum
출처 및 근거
- ORD 기록
- ord-bdab12189dab47a7a6bf709c59d3a49b
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07741321B2
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