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Hydrochloric Acid → {3-[3-(tert-butoxycarbonyl-cyclopropylmethyl-amino)-propylamino]-6-chloro-2-oxo-2H-pyrazin-1-yl}-acetic acid

HRID 1795298
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인쇄 미리보기

반응식

HRID 1795298 반응식
C([O:3][C:4](=[O:30])[CH2:5][N:6]1[C:11]([Cl:12])=[CH:10][N:9]=[C:8]([NH:13][CH2:14][CH2:15][CH2:16][N:17]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:18][CH:19]2[CH2:21][CH2:20]2)[C:7]1=[O:29])C.O.[OH-].[Li+].Cl>O.CO>[C:25]([O:24][C:22]([N:17]([CH2:18][CH:19]1[CH2:20][CH2:21]1)[CH2:16][CH2:15][CH2:14][NH:13][C:8]1[C:7](=[O:29])[N:6]([CH2:5][C:4]([OH:30])=[O:3])[C:11]([Cl:12])=[CH:10][N:9]=1)=[O:23])([CH3:28])([CH3:26])[CH3:27]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 21023631{3-[3-(tert-butoxycarbonyl-cyclopropylmethyl-amino)-propylamino]-6-chloro-2-oxo-2H-pyrazin-1-yl}-acetic acid ethyl ester

생성물 1

HCID 22185165{3-[3-(tert-butoxycarbonyl-cyclopropylmethyl-amino)-propylamino]-6-chloro-2-oxo-2H-pyrazin-1-yl}-acetic acid

시약·촉매·용매 2

HCID 887
Methanol
용매
HCID 962Water용매

실험 절차

A solution of {3-[3-(tert-butoxycarbonyl-cyclopropylmethyl-amino)-propylamino]-6-chloro-2-oxo-2H-pyrazin-1-yl}-acetic acid ethyl ester (0.22 g, 0.50 mmol) and lithium hydroxide monohydrate (27 mg, 0.65 mmol) in water (0.65 ml) and methanol (3 ml) was stirred at room temperature for 1.5 h. hydrochloric acid solution (1N, 0.65 ml) was added and the reaction mixture was stirred at room temperature for 5 min. Concentration from methanol gave {3-[3-(tert-butoxycarbonyl-cyclopropylmethyl-amino)-propylamino]-6-chloro-2-oxo-2H-pyrazin-1-yl}-acetic acid; 1H NMR (CD3OD, 400 MHz) δ 6.90 (s, 1H), 4.90 (s, 2H), 3.34 (m, 4H), 3.11 (d, 2H, J=6.8 Hz), 1.88 (m, 2H), 1.45 (s, 9H), 0.99 (m, 1H), 0.49 (m, 2H), 0.22 (m, 2H).

후처리

  1. additionwas added
  2. concentrationConcentration from methanol

출처 및 근거

ORD 기록
ord-e55785e5cddb4f18a973806cf23bd54d
출처 데이터셋
uspto-grants-2006_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07026324B2

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