Acetyl chloride → Ethanone, 1-(4-octylphenyl)-

HRID 1795496

반응식

HRID 1795496 반응식
[Cl-].[Al+3].[Cl-].[Cl-].[CH2:5]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[C:19](Cl)(=[O:21])[CH3:20]>ClC(Cl)C>[CH2:5]([C:13]1[CH:14]=[CH:15][C:16]([C:19](=[O:21])[CH3:20])=[CH:17][CH:18]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 16607OctylbenzeneHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 66344Ethanone, 1-(4-octylphenyl)-

시약·촉매·용매 1

HCID 63651,1-Dichloroethane용매

실험 절차

Aluminum chloride (22.6 g) is suspended in dichloroethane (500 ml) and octylbenzene (16) (21.5 g) is added at room temperature. To the mixture is added acetyl chloride (8.87 g) under ice-cooling. The mixture is stirred at room temperature overnight. The reaction mixture is poured into ice water and extracted with ether. The organic layer is washed with brine and dried over sodium sulfate. The solvent is evaporated to give 4′-octylacetophenone (18′) as a colorless oil.

후처리

  1. temperaturecooling
  2. extractionextracted with ether
  3. washThe organic layer is washed with brine
  4. dry with materialdried over sodium sulfate
  5. customThe solvent is evaporated

출처 및 근거

ORD 기록
ord-41434725d4704f05bce7715c2da88d02
출처 데이터셋
uspto-grants-2006_04
특허 번호
US07026522B2

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