Ammonium formate → 6-(3-chloropropoxy)-7-methoxyquinazolin-4(3H)-one
반응식
[NH2:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([O:13][CH2:14][CH2:15][CH2:16][Cl:17])=[CH:7][C:3]=1[C:4](O)=[O:5].[CH:18]([O-])=O.[NH4+:21]>C(N)=O>[Cl:17][CH2:16][CH2:15][CH2:14][O:13][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][C:9]=1[O:11][CH3:12])[N:1]=[CH:18][NH:21][C:4]2=[O:5]참가 물질
4
반응 조건
- 온도
- 47.5 °C
실험 절차
2-amino-4-methoxy-5-(3-chloropropoxy)benzoic acid (450 gm), formamide (2250 ml) and ammonium formate (200 gm) were heated to 170-180° C. for 3-4 hours. The reaction mass was concentrated under reduced pressure at 140-150° C. The residue was stirred in methanol (1000 ml) at 45-50° C. and cooled to 5-10° C. The solid obtained was filtered to yield the title compound (420 gm, 90% yield).
후처리
- concentrationThe reaction mass was concentrated under reduced pressure at 140-150° C
- temperaturecooled to 5-10° C
- customThe solid obtained
- filtrationwas filtered
출처 및 근거
- ORD 기록
- ord-6265f294127543ef9d1b5928c01b3d66
- 출처 데이터셋
- uspto-grants-2013_01
- 특허 번호
- US08350029B2
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