Hydrochloric Acid → 2-(3-Benzyloxy-5-trifluoromethyl-phenyl)propionic acid

HRID 1810316노트

반응식

HRID 1810316 반응식
C([O:3][C:4](=[O:25])[CH:5]([C:7]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[C:9]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:8]=1)[CH3:6])C.CO.[Li+].[OH-].Cl>O.C1COCC1>[CH2:18]([O:17][C:9]1[CH:8]=[C:7]([CH:5]([CH3:6])[C:4]([OH:25])=[O:3])[CH:12]=[C:11]([C:13]([F:15])([F:16])[F:14])[CH:10]=1)[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3939Lithium HydroxideHCID 574587982-(3-Benzyloxy-5-trifluoromethyl-phenyl)-propionic acid ethyl ester

생성물 1

HCID 574587992-(3-Benzyloxy-5-trifluoromethyl-phenyl)propionic acid

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

2-(3-Benzyloxy-5-trifluoromethyl-phenyl)-propionic acid ethyl ester (1.4 g, 4.0 mmol) in 2:2:1 MeOH:THF:H2O was treated with 1N aqueous LiOH (3 mL) at room temperature overnight. The mixture was acidified with 10% aqueous HCl and extracted three times with EtOAc. The combined organic layers were concentrated and purified by silica gel chromatography to give the title compound.

후처리

  1. extractionextracted three times with EtOAc
  2. concentrationThe combined organic layers were concentrated
  3. custompurified by silica gel chromatography

출처 및 근거

ORD 기록
ord-e43894cd6b5942ed819db48c47c03528
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362044B2

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