Hydrochloric Acid → Clofibric Acid

HRID 1810390

반응식

HRID 1810390 반응식
C([O:3][C:4](=[O:16])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=1)([CH3:7])[CH3:6])C.[Li+].[OH-].Cl>C1COCC1>[Cl:15][C:12]1[CH:11]=[CH:10][C:9]([O:8][C:5]([CH3:7])([CH3:6])[C:4]([OH:16])=[O:3])=[CH:14][CH:13]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 2796ClofibrateHCID 3939Lithium Hydroxide

생성물 1

HCID 2797Clofibric Acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 2-(4-chlorophenoxy)isobutyric acid ethyl ester (1.0 g, 4.12 mmol) in THF (10 mL) was treated with 1N aqueous LiOH (10 mL) and stirred overnight at room temperature. The mixture was acidified with 1N aqueous HCl to pH 3-4 and extracted three times with EtOAc. The combined organic layers were dried and concentrated to give the title compound.

후처리

  1. extractionextracted three times with EtOAc
  2. customThe combined organic layers were dried
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-fea2d13c4901499cae73c9bc531d3e5a
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362044B2

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