Hydrochloric Acid → 2-(3-Bromo-5-chlorophenyl)propanoic acid
반응식
C([O:3][C:4](=[O:15])[CH:5]([C:7]1[CH:12]=[C:11]([Cl:13])[CH:10]=[C:9]([Br:14])[CH:8]=1)[CH3:6])C.CO.[Li+].[OH-].Cl>O.C1COCC1>[Br:14][C:9]1[CH:8]=[C:7]([CH:5]([CH3:6])[C:4]([OH:15])=[O:3])[CH:12]=[C:11]([Cl:13])[CH:10]=1참가 물질
7
실험 절차
2-(3-Bromo-5-chloro-phenyl)-propionic acid ethyl ester (2.0 g, 6.9 mmol) in 2:2:1 MeOH:THF:H2O was treated with 1N aqueous LiOH (3 mL) and stirred at room temperature overnight. The mixture was acidified with 10% aqueous HCl (10 mL) and extracted three times with EtOAc. The combined organic layers were concentrated, and the residue was purified by silica gel chromatography to give the title compound.
후처리
- extractionextracted three times with EtOAc
- concentrationThe combined organic layers were concentrated
- customthe residue was purified by silica gel chromatography
출처 및 근거
- ORD 기록
- ord-599c298e55234cdda993562fd6b1f280
- 출처 데이터셋
- uspto-grants-2013_01
- 특허 번호
- US08362044B2
반응 노트
불러오는 중…