Hydrochloric Acid → 3-Benzyloxy-4-(1-tert-butoxycarbonylmethyl-2,2-diethyoxy-ethylsulfamoyl-)benzoic acid

HRID 1814358노트

반응식

HRID 1814358 반응식
C[O:2][C:3](=[O:38])[C:4]1[CH:9]=[CH:8][C:7]([S:10](=[O:29])(=[O:28])[NH:11][CH:12]([CH2:20][C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH:13]([O:17][CH2:18][CH3:19])[O:14][CH2:15][CH3:16])=[C:6]([O:30][CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:5]=1.[OH-].[Li+].Cl>C(OCC)(=O)C>[CH2:31]([O:30][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[S:10](=[O:28])(=[O:29])[NH:11][CH:12]([CH2:20][C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH:13]([O:17][CH2:18][CH3:19])[O:14][CH2:15][CH3:16])[C:3]([OH:38])=[O:2])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 697315433-Benzyloxy-4-(1-tert-butoxycarbonylmethyl-2,2-diethoxy-ethylsulfamoyl)-benzoic acid methyl ester

생성물 1

HCID 1317248233-Benzyloxy-4-(1-tert-butoxycarbonylmethyl-2,2-diethyoxy-ethylsulfamoyl-)benzoic acid수율 65%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

3-Benzyloxy-4-(1-tert-butoxycarbonylmethyl-2,2-diethoxy-ethylsulfamoyl)-benzoic acid methyl ester (6.82 g, 12.4 mmol) was combined and stirred with 1M lithium hydroxide (26 mL, 26 mmol) in tetrohydrofuran (250 mL) at room temperature overnight. The reaction mixture was diluted with ethyl acetate and acidified with 1M HCl (26 mL). The organic layer was collected and extracted with water, brine, dried over magnesium sulfate, filtered, and concentrated under reduced pressure to give 3-benzyloxy-4-(1-tert-butoxycarbonylmethyl-2,2-diethyoxy-ethylsulfamoyl-)benzoic acid (4.32 g, 8.0 mmol, 65%). MS (APCI) m/z 536.3 (M−1).

후처리

  1. customThe organic layer was collected
  2. extractionextracted with water, brine
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-b2824492aa2a4b70be01d1cda49bc815
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06875765B2

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