Hydrochloric Acid → cis-2,6-Dimethyl-4-(4-piperazinylphenyl)morpholine

HRID 1816751노트

반응식

HRID 1816751 반응식
[CH3:1][C@H:2]1[O:7][C@@H:6]([CH3:8])[CH2:5][N:4]([C:9]2[CH:14]=[CH:13][C:12]([N:15]3[CH2:20][CH2:19][N:18](C(=O)C)[CH2:17][CH2:16]3)=[CH:11][CH:10]=2)[CH2:3]1.Cl.[OH-].[Na+].ClCCl>C(O)C>[CH3:8][C@H:6]1[O:7][C@@H:2]([CH3:1])[CH2:3][N:4]([C:9]2[CH:10]=[CH:11][C:12]([N:15]3[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]3)=[CH:13][CH:14]=2)[CH2:5]1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 14798Sodium HydroxideHCID 540805081-[4-[4-(cis-2,6-Dimethylmorpholin-4-yl)phenyl]piperazin-1-yl]ethanone

생성물 1

HCID 69677628cis-2,6-Dimethyl-4-(4-piperazinylphenyl)morpholine수율 36.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture 1-[4-[4-(cis-2,6-dimethylmorpholin-4-yl)phenyl]piperazin-1-yl]ethanone (11.37 g) and 1.0 mol/l hydrochloric acid (225 ml) in ethanol (220 ml) was refluxed for 23 hours. The reaction mixture was added to a mixture of 1.0 mol/l sodium hydroxide solution and dichloromethane. The organic layer was taken and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was concentrated under reduced pressure to give cis-2,6-dimethyl-4-(4-piperazinylphenyl)morpholine (3.64 g).

후처리

  1. dry with materialdried over magnesium sulfate
  2. filtrationThe magnesium sulfate was filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-32c120474e334b5f942fc3af8fca638a
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06884868B1

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