Triethylamine → HCID 57881597, 화합물

HRID 1817418노트

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HRID 1817418 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][CH:17]=1.C(N(CC)CC)C.ClC(Cl)(O[C:34](=[O:40])OC(Cl)(Cl)Cl)Cl.Cl.[N+:43]([C:46]1[CH:51]=[CH:50][C:49]([C@@H:52]([NH2:54])[CH3:53])=[CH:48][CH:47]=1)([O-:45])=[O:44]>C(Cl)(Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:22]=[CH:21][C:19]([NH:20][C:34]([NH:54][C@H:52]([C:49]2[CH:48]=[CH:47][C:46]([N+:43]([O-:45])=[O:44])=[CH:51][CH:50]=2)[CH3:53])=[O:40])=[CH:18][CH:17]=1

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 94429TriphosgeneHCID 115945434-[(6,7-Dimethoxyquinolin-4-yl)oxy]anilineHCID 16212176(1S)-1-(4-Nitrophenyl)ethan-1-amine--hydrogen chloride (1/1)

생성물 1

HCID 57881597HCID 57881597, 화합물수율 127%

시약·촉매·용매 1

HCID 6212Chloroform용매3회

실험 절차

4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline (70 mg) was dissolved in chloroform (1 ml) and triethylamine (0.14 ml) to prepare a solution. A solution of triphosgene (33 mg) in chloroform (0.2 ml) was then added to the solution, and the mixture was stirred at room temperature for 75 min. Next, a solution of (1S)-1-(4-nitrophenyl)ethylamine hydrochloride (47 mg) in chloroform (0.2 ml) was added thereto, and the mixture was stirred at room temperature for 10 hr. The stirred mixture was purified by chromatography on silica gel using chloroform/methanol for development to give the title compound (69 mg, yield 60%).

후처리

  1. stirringthe mixture was stirred at room temperature for 10 hr
  2. customThe stirred mixture was purified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-910a883b5aff49c4914d8a816d06a586
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07598258B2

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