Hydrochloric Acid → 1-(2-Methoxy-5-propylphenyl)ethanone

HRID 1817842

반응식

HRID 1817842 반응식
[Al+3].[Cl-].[Cl-].[Cl-].[C:5](Cl)([CH3:7])=[O:6].[CH2:9]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)[CH2:10][CH3:11].Cl>ClCCl>[CH3:19][O:18][C:15]1[CH:16]=[CH:17][C:12]([CH2:9][CH2:10][CH3:11])=[CH:13][C:14]=1[C:5](=[O:6])[CH3:7]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 77024-PropylanisoleHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 684544751-(2-Methoxy-5-propylphenyl)ethanone

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
-10 °C

실험 절차

A suspension of 10.6 g of AlCl3 in 150 mL of dichloromethane is cooled to −10° C. 5.7 mL of AcCl and 6 g of 4-propylanisole are added. The medium is stirred for 30 minutes at −10° C. and then poured into a beaker containing ice mixed with 35% HCl. After separation of the phases by settling, the aqueous phase is extracted 3 times with DCM and the combined organic phases are washed with water, with saturated NaCl solution, dried over MgSO4 and then evaporated to give 7.86 g of a brown oil.

후처리

  1. additionpoured into a beaker
  2. additioncontaining ice
  3. customAfter separation of the phases
  4. extractionthe aqueous phase is extracted 3 times with DCM
  5. washthe combined organic phases are washed with water, with saturated NaCl solution
  6. dry with materialdried over MgSO4
  7. customevaporated

출처 및 근거

ORD 기록
ord-d2998c6f826c4f83a989bb45635e8b74
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07598392B2

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