Hydrochloric Acid → HCID 44627932, 화합물

HRID 1817989노트

반응식

HRID 1817989 반응식
C[O:2][C:3](=[O:16])/[CH:4]=[CH:5]/[C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:14]=1[NH:13][CH:12]=[C:11]2[CH3:15].Cl>C1COCC1.CO.[OH-].[Na+]>[CH3:15][C:11]1[C:10]2[C:14](=[C:6](/[CH:5]=[CH:4]/[C:3]([OH:16])=[O:2])[CH:7]=[CH:8][CH:9]=2)[NH:13][CH:12]=1

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 44627931HCID 44627931, 화합물

생성물 1

HCID 44627932HCID 44627932, 화합물

시약·촉매·용매 3

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매HCID 14798Sodium Hydroxide용매

실험 절차

(I-7). To a solution of (E)-3-(3-methyl-1H-indol-7-yl)-acrylic acid methyl ester (2, 180 mg, 0.84 mmol) in THF (5 ml) and methanol (4 ml), NaOH aq. (4 ml) was added at rt. The reaction mixture was stirred at rt over night and then the pH was adjusted to acidic by adding aqueous 2N HCl. The reaction mixture was extracted with EtOAc (2×30 ml). The combined organic phases were washed with water, brine and dried over sodium sulfate. After removal of solvent, 170 mg of I-7 was obtained. 1H-NMR (500 MHz, DMSO-d6).

후처리

  1. extractionThe reaction mixture was extracted with EtOAc (2×30 ml)
  2. washThe combined organic phases were washed with water, brine
  3. dry with materialdried over sodium sulfate
  4. customAfter removal of solvent, 170 mg of
  5. customI-7 was obtained

출처 및 근거

ORD 기록
ord-6822edf6532146fca2463bcfe49b7115
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07598397B2

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