Hydrochloric Acid → 3-(4-Chlorophenoxy)-2-hydroxypropanoic acid

HRID 1818654

반응식

HRID 1818654 반응식
Cl[CH2:2][CH:3]([OH:7])[C:4]([OH:6])=[O:5].[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1.Cl>[OH-].[Na+]>[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:2][CH:3]([OH:7])[C:4]([OH:6])=[O:5])=[CH:11][CH:10]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 46844-ChlorophenolHCID 92899Chlorolactic acid

생성물 1

HCID 1011743-(4-Chlorophenoxy)-2-hydroxypropanoic acid

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

A mixture of 3-chlorolactic acid (5.0 g, 40 mmol) and 4-chlorophenol (9.3 g, 72 mmol) in 40 ml 3.3 N sodium hydroxide is stirred under reflux for 2 hours. Subsequently the reaction mixture is cooled to room temperature and acidified to pH 3 with concentrated hydrochloric acid. The resulting white crystals are filtered and dissolved in hot water. This hot solution is adjusted to pH 1 with concentrated sulfuric acid. Upon cooling, 3-(4-chloro-phenoxy)-2-hydroxy-propionic acid is collected as clear crystals.

후처리

  1. temperatureunder reflux for 2 hours
  2. filtrationThe resulting white crystals are filtered
  3. dissolutiondissolved in hot water
  4. temperatureUpon cooling
  5. custom3-(4-chloro-phenoxy)-2-hydroxy-propionic acid is collected as clear crystals

출처 및 근거

ORD 기록
ord-cadb6168f7b34800a7d72c0443097b44
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07601674B2

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