Hydrochloric Acid → 2-(Methanesulfonyl)benzylamine hydrochloride
반응식
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[S:15]([CH3:18])(=[O:17])=[O:16])(C)(C)C.[ClH:20]>O1CCOCC1.C(Cl)(Cl)Cl>[ClH:20].[CH3:18][S:15]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[CH2:8][NH2:7])(=[O:16])=[O:17]참가 물질
5
실험 절차
(2-Methanesulfonyl-benzyl)-carbamic acid tert-butyl ester (1.55 g, 5.43 mmol) was dissolved in warm dioxane (50 mL) and cooled to room temperature. HCl solution (4M solution in dioxane, 20 ml, 80 mmol) was added. After 20 h, a white precipitate had formed. The reaction was diluted with CHCl3 (50 mL) and filtered. The white solid was washed with CHCl3 and dried in-vacuo to yield 1.075g of 2-methanesulfonyl-benzylamine hydrochloride as an off white solid, m/z 186.6 (M+1)+.
후처리
- customa white precipitate had formed
- filtrationfiltered
- washThe white solid was washed with CHCl3
- customdried in-vacuo
출처 및 근거
- ORD 기록
- ord-9a10e61025534704825a2a2dc82d2516
- 출처 데이터셋
- uspto-grants-2009_10
- 특허 번호
- US07601714B2
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