Water → Tert-butyl 3-(2-isopropylphenoxy)propionate

HRID 1819503노트

반응식

HRID 1819503 반응식
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10])([CH3:3])[CH3:2].C(OC(C)(C)C)(C)(C)C.[K].O.[C:22]([O:26][C:27](=[O:30])[CH:28]=[CH2:29])([CH3:25])([CH3:24])[CH3:23]>>[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[O:10][CH2:29][CH2:28][C:27]([O:26][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:30])([CH3:3])[CH3:2]

참가 물질

5

반응물 4

HCID 962WaterHCID 69432-IsopropylphenolHCID 15458tert-Butyl acrylateHCID 86607002Potassium tert-butyloxide

생성물 1

HCID 23119473Tert-butyl 3-(2-isopropylphenoxy)propionate수율 36.9%

반응 조건

온도
130 °C

실험 절차

2-Isopropylphenol (6 g) was dissolved in acrylic acid tert-butyl ester (6.2 g), and to the mixture was added potassium tert-butyloxide (0.3 g). The reaction mixture was stirred at 130° C. for 6 h. To the reaction mixture was added water, the reaction mixture extracted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate, and evaporated. The obtained residue was purified by column chromatography (hexane:ethyl acetate=9:1) to obtain the compound (10) 4.3 g.

후처리

  1. extractionthe reaction mixture extracted with ethyl acetate
  2. washThe organic layer was washed with brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated
  5. customThe obtained residue was purified by column chromatography (hexane:ethyl acetate=9:1)

출처 및 근거

ORD 기록
ord-f08906a112a2445eb2d6592526fe52b8
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07601746B2

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