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Hydrochloric Acid → HCID 23119447, 화합물

HRID 1819506
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HRID 1819506 반응식
C([O:3][C:4](=[O:35])/[C:5](/[CH3:34])=[CH:6]/[C:7]1[C:12]([F:13])=[CH:11][C:10]([C:14](=[O:32])[NH:15][C:16]2[S:17][C:18]3[CH2:28][O:27][C:26]4[C:25]([CH:29]([CH3:31])[CH3:30])=[CH:24][CH:23]=[CH:22][C:21]=4[C:19]=3[N:20]=2)=[CH:9][C:8]=1[F:33])C.CO.[OH-].[Na+].Cl>C1COCC1>[F:33][C:8]1[CH:9]=[C:10]([C:14](=[O:32])[NH:15][C:16]2[S:17][C:18]3[CH2:28][O:27][C:26]4[C:25]([CH:29]([CH3:31])[CH3:30])=[CH:24][CH:23]=[CH:22][C:21]=4[C:19]=3[N:20]=2)[CH:11]=[C:12]([F:13])[C:7]=1/[CH:6]=[C:5](\[CH3:34])/[C:4]([OH:35])=[O:3]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 57887231HCID 57887231, 화합물

생성물 1

HCID 23119447HCID 23119447, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

(E)-3-[2,6-difluoro-4-(6-isopropyl-4H-chromeno[4,3-d]thiazol-2-ylcarbamoyl)phenyl]-2-methylacrylic acid ethyl ester (620 mg) was dissolved in THF (2 mL), methanol (2 ml), and 2N sodium hydroxide aqueous solution (2 mL), and the reaction mixture was stirred at room temperature for 3 h. The reaction mixture was acidified with hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with water, and brine, dried over magnesium sulfate, and evaporated. The residue was recrystallized from ethyl acetate to obtain the compound (A1309) 460 mg.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water, and brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated
  5. customThe residue was recrystallized from ethyl acetate
  6. customto obtain the compound (A1309) 460 mg

출처 및 근거

ORD 기록
ord-f8d86173912642c5bebdb062f767b26c
출처 데이터셋
uspto-grants-2009_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07601746B2

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