Chloroform → Phenacyl bromide

HRID 18200

반응식

HRID 18200 반응식
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2].C(Cl)(Cl)Cl.[Br:14]Br>C(OCC)C.C(Cl)Cl.C(O)(=O)C>[Br:14][CH2:2][C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:3]

참가 물질

7

반응물 3

HCID 6212ChloroformHCID 7410Acetophenone3회HCID 24408Bromine2회

생성물 1

HCID 6259Phenacyl bromide

시약·촉매·용매 3

HCID 176Acetic Acid촉매HCID 3283Diethyl Ether용매2회HCID 6344Dichloromethane용매2회

실험 절차

The appropriate acetophenone (Intermediate A) was dissolved in diethyl ether, methylene chloride, or chloroform, and cooled to 0° C. Bromine (1.1 equiv) was dissolved in either methylenechloride or diethyl ether and added to the solution of acetophenone via a dropping funnel. After the addition of bromine was complete 2 drops of acetic acid were added and the solution was warmed to room temperature. Solvent was removed under reduced pressure to provide crude 2-bromoacetophenone (Intermediate B) which was generally used without further purification.

후처리

  1. additionwere added
  2. customSolvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-0ad0056e4b8948658799532f1f4e42e6
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741349B2

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