Hydrochloric Acid → 2,6-Dimethyl-4-nitroaniline

HRID 1820117

반응식

HRID 1820117 반응식
Cl.[CH3:2][C:3]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[C:5]([CH3:12])[C:4]=1[NH:13]C(=O)C.C(=O)([O-])[O-].[Na+].[Na+]>O>[CH3:2][C:3]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[C:5]([CH3:12])[C:4]=1[NH2:13]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 50851089N-(2,6-dimethyl-4-nitrophenyl)acetamide

생성물 1

HCID 281592,6-Dimethyl-4-nitroaniline수율 97.5%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
140 °C

실험 절차

Concentrated hydrochloric acid (17.5 mL) was added to N-(2,6-dimethyl-4-nitro-phenyl)-acetamide (5.05 g) and heated to 140° C. for 30 minutes in a sealed microwave process vial. The reaction mixture was neutralized with solid sodium carbonate in water and the precipitated product was collected by filtration and washed with water (100 mL) to furnish 3.93 g (97% yield) of the title compound as a yellow solid. 1H NMR (500 MHz, DMSO-d6): 2.15 (s, 6H), 6.15 (b, 2H), 7.79 (s, 2H).

후처리

  1. filtrationthe precipitated product was collected by filtration
  2. washwashed with water (100 mL)

출처 및 근거

ORD 기록
ord-6495e0fce7c44ab6b87b955008f683f2
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07601870B2

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