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Benzenesulfonamide → n-(2-Hydroxy-indan-1-yl)-2-[4-(6-methoxy-3-phenyl-naphthalen-1-yloxy)-2-(1-phenylmethanesulfonylaminocarbonyl-2-vinyl-cyclopropyl)-pyrrolidin-1-yl]-3,3-dimethyl-butyramide

HRID 1822434
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HRID 1822434 반응식
[OH:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]1[NH:11][C:12]([CH:14]([N:19]1[CH2:23][CH:22]([O:24][C:25]2[C:34]3[C:29](=[CH:30][C:31]([O:35][CH3:36])=[CH:32][CH:33]=3)[CH:28]=[C:27]([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[CH:26]=2)[CH2:21][CH:20]1[C:43]1([C:48](O)=[O:49])[CH2:45][CH:44]1[CH:46]=[CH2:47])[C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13].[C:51]1([S:57]([NH2:60])(=[O:59])=[O:58])C=CC=CC=1.C(N([CH:67]([CH3:69])[CH3:68])CC)(C)C.[CH2:70]1[CH2:74]N([P+](ON2N=NC3C=CC=CC2=3)(N2CCCC2)N2CCCC2)C[CH2:71]1.F[P-](F)(F)(F)(F)F.C([O-])(O)=O.[Na+]>C(Cl)(Cl)Cl>[OH:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]1[NH:11][C:12](=[O:13])[CH:14]([N:19]1[CH2:23][CH:22]([O:24][C:25]2[C:34]3[C:29](=[CH:30][C:31]([O:35][CH3:36])=[CH:32][CH:33]=3)[CH:28]=[C:27]([C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=3)[CH:26]=2)[CH2:21][CH:20]1[C:43]1([C:48]([NH:60][S:57]([CH2:51][C:68]2[CH:67]=[CH:69][CH:74]=[CH:70][CH:71]=2)(=[O:59])=[O:58])=[O:49])[CH2:45][CH:44]1[CH:46]=[CH2:47])[C:15]([CH3:16])([CH3:18])[CH3:17]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 5

HCID 7370BenzenesulfonamideHCID 81531DiisopropylethylamineHCID 516892Sodium BicarbonateHCID 2724699PyBOPHCID 68493461HCID 68493461, 화합물

생성물 1

HCID 68493430
n-(2-Hydroxy-indan-1-yl)-2-[4-(6-methoxy-3-phenyl-naphthalen-1-yloxy)-2-(1-phenylmethanesulfonylaminocarbonyl-2-vinyl-cyclopropyl)-pyrrolidin-1-yl]-3,3-dimethyl-butyramide

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To solution of 14 (25 mg, 0.033 mmol) in chloroform (1 mL) was added benzenesulfonamide (10.5 mg, 0.066 mmol) followed by diisopropylethylamine (34 μL, 0.197 mmol). The solution was stirred at RT for 10 min and then at −20° C. for 30 min. PyBOP (76 mg, 0.13 mmol) was then added as a solid. The solution was kept at −20° C. for 48 hours. The solution was then poured into aqueous NaHCO3 (sat.) and washed with water. The organic layer was dried, concentrated and subjected to purification by HPLC, affording the title compound as a white solid.

후처리

  1. waitat −20° C. for 30 min
  2. waitThe solution was kept at −20° C. for 48 hours
  3. washwashed with water
  4. customThe organic layer was dried
  5. concentrationconcentrated
  6. customsubjected to purification by HPLC

출처 및 근거

ORD 기록
ord-ec00197691184e7fbdb8f315c7ccf945
출처 데이터셋
uspto-grants-2009_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07608590B2

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