Sodium Hydroxide → HCID 131725722, 화합물

HRID 1822749노트

반응식

HRID 1822749 반응식
[C:1]1([C:7]2[N:12]=[C:11]3[CH:13]=[CH:14][N:15]=[CH:16][C:10]3=[C:9]([C:17]([OH:19])=O)[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.F[P-](F)(F)(F)(F)F.[N:27]1(O[P+](N(C)C)(N(C)C)N(C)C)C2C=CC=CC=2N=N1.C1([C@@H](N)CC)C=CC=CC=1.[OH-].[Na+]>CC(N(C)C)=O.ClC(Cl)C.C(N(CC)CC)C>[C:1]1([C:7]2[N:12]=[C:11]3[CH:13]=[CH:14][N:15]=[CH:16][C:10]3=[C:9]([C:17]([NH2:27])=[O:19])[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

8

반응물 4

HCID 14798Sodium HydroxideHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 6993773(1S)-1-phenylpropan-1-amineHCID 106821072-Phenyl-[1,6]naphthyridine-4-carboxylic acid

생성물 1

HCID 131725722HCID 131725722, 화합물

시약·촉매·용매 3

HCID 63651,1-Dichloroethane용매HCID 8471Triethylamine용매HCID 31374Dimethylacetamide용매

실험 절차

To a solution of 250 mg of 2-phenylpyridino[4,3-b]pyridin-4-yl carboxylic acid dissolved in 5 mL of dimethylacetamide and 200 uL of triethylamine is added 500 mg of BOP in 5 mL of dichloroethane followed by 150 mg of (S)-1-phenylpropylamine. The reaction mixture is stirred for 16 hours at room temperature. The reaction mixture is poured onto 50 mL of 1N NaOH and the product is extracted with 25 mL of ethyl acetate. After drying over magnesium sulfate the solvent is removed in vacuo to afford N—[(S)-1-phenyl-1-propyl)]-(2-phenylpyridino[4,3-b]pyridin-4-yl)carboxamide as a solid.

후처리

  1. extractionthe product is extracted with 25 mL of ethyl acetate
  2. dry with materialAfter drying over magnesium sulfate the solvent
  3. customis removed in vacuo

출처 및 근거

ORD 기록
ord-9f9a46d99877422791292d7e71a718a4
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07037922B1

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