Acetic Anhydride → Acetamide, N-(4-hydroxy-2,5-dimethylphenyl)-

HRID 1822898

반응식

HRID 1822898 반응식
[NH2:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([OH:9])=[C:4]([CH3:10])[CH:3]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>O>[OH:9][C:5]1[C:4]([CH3:10])=[CH:3][C:2]([NH:1][C:11](=[O:13])[CH3:12])=[C:7]([CH3:8])[CH:6]=1

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 765444-Amino-2,5-dimethylphenol

생성물 1

HCID 155307Acetamide, N-(4-hydroxy-2,5-dimethylphenyl)-수율 90.4%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
70 °C

실험 절차

To a suspension of 4-amino-2,5-dimethyl-phenol (6.85 g, 50 mmol) in 30 mL of water was added acetic anhydride (5.67 mL, 60 mmol). The mixture was vigorously stirred at 70° C. for 20 min and then cooled down to room temperature. The solid was collected by filtration and washed with water to give N-(4-hydroxy-2,5-dimethyl-phenyl)-acetamide as gray solid (8.1 g, 90%).

후처리

  1. temperaturecooled down to room temperature
  2. filtrationThe solid was collected by filtration
  3. washwashed with water

출처 및 근거

ORD 기록
ord-319565c3bd714555a2d8cd31a5c25312
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07037909B2

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