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Hydrochloric Acid → 3-(3-Methyl-4-oxo-5H-2-oxa-1,5,7-triaza-cyclopenta[a]naphthalen-5-yl)-cyclohexanecarboxylic acid

HRID 1823296
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HRID 1823296 반응식
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][CH2:9][CH:8]([N:12]2[C:21]3[C:16](=[CH:17][CH:18]=[N:19][CH:20]=3)[C:15]3=[N:22][O:23][C:24]([CH3:25])=[C:14]3[C:13]2=[O:26])[CH2:7]1)=[O:5])C.[OH-].[Na+].C(O)C.Cl>O.O1CCCC1>[CH3:25][C:24]1[O:23][N:22]=[C:15]2[C:16]3[C:21](=[CH:20][N:19]=[CH:18][CH:17]=3)[N:12]([CH:8]3[CH2:9][CH2:10][CH2:11][CH:6]([C:4]([OH:5])=[O:3])[CH2:7]3)[C:13](=[O:26])[C:14]=12
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참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 696526573-(3-Methyl-4-oxo-5h-2-oxa-1,5,7-triaza-cyclopenta[a]naphthalen-5-yl)-cyclohexanecarboxylic acid ethyl ester

생성물 1

HCID 221701653-(3-Methyl-4-oxo-5H-2-oxa-1,5,7-triaza-cyclopenta[a]naphthalen-5-yl)-cyclohexanecarboxylic acid수율 88%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

Combine 3-(3-methyl-4-oxo-5H-2-oxa-1,5,7-triaza-cyclopenta[a]naphthalen-5-yl)-cyclohexane-carboxylic acid ethyl ester (620 mg, 1.75 mmol) with aqueous sodium hydroxide (2N, 5.0 mL, 10.0 mmol), ethanol (2 mL), and tetrahydrofuran (2 mL) and stir at ambient temperature until hydrolysis is complete. Add water and adjust to approx. pH 3.0 with aqueous hydrochloric acid. Extract with dichloromethane and dry over sodium sulfate and concentrate in vacuo to give the desired acid as a tan solid (500 mg, 88%).

후처리

  1. extractionExtract with dichloromethane
  2. dry with materialdry over sodium sulfate
  3. concentrationconcentrate in vacuo

출처 및 근거

ORD 기록
ord-dc98c1d5c540450194d37a1edb7af438
출처 데이터셋
uspto-grants-2006_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07037921B2

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