Methyl Methacrylate → Cholesterol

HRID 1823698노트

반응식

HRID 1823698 반응식
CCCCCCCCC([O:11][C@@H:12]1[CH2:25][C:24]2[C@@:15]([CH3:38])([C@@H:16]3[C@@H:21]([CH2:22][CH:23]=2)[C@@H:20]2[CH2:26][CH2:27][C@H:28]([C@@H:29]([CH2:31][CH2:32][CH2:33][CH:34]([CH3:36])[CH3:35])[CH3:30])[C@@:19]2([CH3:37])[CH2:18][CH2:17]3)[CH2:14][CH2:13]1)=O.COC(=O)C(C)=C.N(C(C)(CC)C#N)=NC(C)(CC)C#N.[N+]([O-])([O-])=O.[Na+]>C(Cl)Cl>[CH3:36][CH:34]([CH2:33][CH2:32][CH2:31][C@H:29]([C@@H:28]1[C@:19]2([CH3:37])[C@H:20]([C@H:21]3[C@H:16]([CH2:17][CH2:18]2)[C@:15]2([CH3:38])[C:24]([CH2:25][C@H:12]([CH2:13][CH2:14]2)[OH:11])=[CH:23][CH2:22]3)[CH2:26][CH2:27]1)[CH3:30])[CH3:35]

참가 물질

6

반응물 4

HCID 6658Methyl MethacrylateHCID 24268Sodium NitrateHCID 930792,2'-Azobis(2-methylbutyronitrile)HCID 2723614Cholesteryl Nonanoate

생성물 1

HCID 5997Cholesterol

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
60 °C

실험 절차

30 wt % of cholesteryl nonanoate and 70 wt % of methylmethacrylate monomer were dissolved uniformly in 20 ml of methylene chloride under irradiation of ultrasonic wave. As an initiator, 2,2′-azobis(2-methylbutyronitrile) was added thereto in an amount of 1 wt % based on the weight of monomer. The obtained solution was added into 1.5% aqueous solution of polyvinyl alcohol with 87˜89% of saponification value and then was emulsified under 5,000 rpm of shear stress for 5 minutes. The emulsion and 0.01 wt % of sodium nitrate were introduced into the reactor heated at 60° C. and then polymerized for 4 hours. After the polymerization was terminated, the organic solvent was evaporated off under reduced pressure. The residue was filtrated, washed with distilled water several times, and then dried on vacuum oven, to give cholesterol liquid crystal polymer microcapsules as powders.

후처리

  1. custompolymerized for 4 hours
  2. customAfter the polymerization was terminated
  3. customthe organic solvent was evaporated off under reduced pressure
  4. filtrationThe residue was filtrated
  5. washwashed with distilled water several times
  6. customdried on vacuum oven

출처 및 근거

ORD 기록
ord-b7ff2b3d31c34acfbba430d7754815b2
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07041304B2

반응 노트

불러오는 중…