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Sodium Dithionite → 4-(Cyclopropylmethyl-amino)-benzenesulfonic acid 3,4-diamino-phenyl ester

HRID 1823781
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HRID 1823781 반응식
S(S([O-])=O)([O-])=O.[Na+].[Na+].[NH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][S:17]([C:20]2[CH:25]=[CH:24][C:23]([NH:26][CH2:27][CH:28]3[CH2:30][CH2:29]3)=[CH:22][CH:21]=2)(=[O:19])=[O:18])=[CH:12][C:11]=1[N+:31]([O-])=O.[Na]>C(O)C>[NH2:31][C:11]1[CH:12]=[C:13]([O:16][S:17]([C:20]2[CH:25]=[CH:24][C:23]([NH:26][CH2:27][CH:28]3[CH2:29][CH2:30]3)=[CH:22][CH:21]=2)(=[O:19])=[O:18])[CH:14]=[CH:15][C:10]=1[NH2:9]
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참가 물질

5

반응물 3

HCID 24489Sodium DithioniteHCID 5360545SodiumHCID 865960784-(Cyclopropylmethyl-amino)-benzenesulfonic acid 4-amino-3-nitro-phenyl ester

생성물 1

HCID 865960794-(Cyclopropylmethyl-amino)-benzenesulfonic acid 3,4-diamino-phenyl ester수율 90.8%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

Sodium dithionite (3 g) was added to a solution of 4-(cyclopropylmethyl-amino)-benzenesulfonic acid 4-amino-3-nitro-phenyl ester (783 mg) and sodium hydroxyde (0.5 N, 15 ml) in ethanol (30 ml) at 80° C. The reaction mixture was stirred at 80° C. for 10 minutes then filtered then the filtrate was evaporated. The residue was extracted three times with ethyl acetate (30 ml). The combined extracts were dried over magnesium sulfate then evaporated to give 652 mg of 4-(cyclopropylmethyl-amino)-benzenesulfonic acid 3,4-diamino-phenyl ester.

후처리

  1. filtrationthen filtered
  2. customthe filtrate was evaporated
  3. extractionThe residue was extracted three times with ethyl acetate (30 ml)
  4. dry with materialThe combined extracts were dried over magnesium sulfate
  5. customthen evaporated

출처 및 근거

ORD 기록
ord-f49c417d71884c3faacbe21f3670e29d
출처 데이터셋
uspto-grants-2006_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07041668B2

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