2-[4-[(2,3-Epoxy)propoxy]phenyl]-8-methylimidazo[1,2-a]pyridine → 2-[4-(2-Hydroxy-3-propylaminopropoxy)phenyl]-8-methylimidazo[1,2-a]pyridine

HRID 1824554

반응식

HRID 1824554 반응식
[O:1]1[CH2:21][CH:2]1[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[C:13]3[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][N:14]3[CH:20]=2)=[CH:7][CH:6]=1>C(N)CC>[OH:1][CH:2]([CH2:21][NH:12][CH2:11][CH2:8][CH3:7])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[C:13]3[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][N:14]3[CH:20]=2)=[CH:7][CH:6]=1

참가 물질

3

반응물 1

HCID 220156322-[4-[(2,3-Epoxy)propoxy]phenyl]-8-methylimidazo[1,2-a]pyridine

생성물 1

HCID 220156042-[4-(2-Hydroxy-3-propylaminopropoxy)phenyl]-8-methylimidazo[1,2-a]pyridine

시약·촉매·용매 1

HCID 7852Propylamine용매

실험 절차

The product of Step C (5.0 g) and propylamine (20 mL) was heated at 40° C. for 18 hours. The reaction was cooled to ambient temperature evaporated and the residue purified via silica gel chromatography (dichloromethane/methanol) to give the title compound which was converted to a HCl salt upon treatment with HCl/methanol.

후처리

  1. customevaporated
  2. customthe residue purified via silica gel chromatography (dichloromethane/methanol)

출처 및 근거

ORD 기록
ord-b89a0f4cb6f043ba843623570e4eed85
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07041828B2

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