Phosphorus oxychloride → HCID 11196721, 화합물

HRID 1824720

반응식

HRID 1824720 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16](O)[C:15]3[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=3[N:9]=2)=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:21])=O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16]([Cl:21])[C:15]3[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=3[N:9]=2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 178517489HCID 178517489, 화합물

생성물 1

HCID 11196721HCID 11196721, 화합물

실험 절차

8.0 g of 2-(4-chlorophenyl)-4-hydroxy-5,6,7,8-tetrahydroquinazoline were heated to 100° C. in 10 ml of phosphorus oxychloride. After 3 hours, the cooled solution was carefully poured onto ice water. The crystalline product was filtered off with suction, washed well with water and dried in vacuo at room temperature. Yield: 6.2 g; m.p.: 121° C.

후처리

  1. additionthe cooled solution was carefully poured onto ice water
  2. filtrationThe crystalline product was filtered off with suction
  3. washwashed well with water
  4. customdried in vacuo at room temperature

출처 및 근거

ORD 기록
ord-17378f48516545b6a8122404210c0143
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07045526B2

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