홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Hydrochloric Acid → 2-[5-(4-Fluorophenyl)-3-pyridylmethylaminomethyl]chroman hydrochloride

HRID 1825291
노트
인쇄 미리보기

반응식

HRID 1825291 반응식
[ClH:1].[NH2:2][CH2:3][CH:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[O:5]1.C[O-].[Na+].[F:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:25]=[C:26]([CH:30]=O)[CH:27]=[N:28][CH:29]=2)=[CH:20][CH:19]=1.[BH4-].[Na+].Cl>CO.O>[ClH:1].[F:17][C:18]1[CH:19]=[CH:20][C:21]([C:24]2[CH:25]=[C:26]([CH2:30][NH:2][CH2:3][CH:4]3[CH2:13][CH2:12][C:11]4[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=4)[O:5]3)[CH:27]=[N:28][CH:29]=2)=[CH:22][CH:23]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

8

반응물 5

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 98776715-(4-Fluorophenyl)pyridine-3-carbaldehydeHCID 10942334Sodium MethoxideHCID 22145477(3,4-dihydro-2H-1-benzopyran-2-yl)methanamine hydrochloride

생성물 1

HCID 221454802-[5-(4-Fluorophenyl)-3-pyridylmethylaminomethyl]chroman hydrochloride
수율 72.2%

시약·촉매·용매 2

HCID 887Methanol용매2회HCID 962Water용매

반응 조건

온도
0 °C

실험 절차

20.27 g of 2-aminomethylchroman hydrochloride are introduced into 130 g of methanol, and 20.4 g of a 30% sodium methoxide solution in methanol are subsequently added. 20.43 g of 5-(4-fluorophenyl)pyridine-3-carbaldehyde are added to the white suspension at 35° C., and the mixture is stirred for 1.5 hours before 4.20 g of sodium borohydride are added in portions. After 15 hours, 56.4 ml of water are added, and the pH of the mixture is adjusted to pH 2 using 37% hydrochloric acid. After the suspension has been cooled to 0° C., the crystals are filtered off, washed with methanol and dried under reduced pressure, giving 28.2 g of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman hydrochloride (64% yield).

후처리

  1. additionare subsequently added
  2. additionare added in portions
  3. filtrationthe crystals are filtered off
  4. washwashed with methanol
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-0e5ca059b7cb42afb5e2487cf0e705cc
출처 데이터셋
uspto-grants-2006_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07045629B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트