Dimethylformamide → (E)-2-{8-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-4-oxo-2-(tetrahydro-3-furanylmethoxy)-4H-pyrido[1,2-a]pyrimidin-3-yl}-1-ethenylcyanide

HRID 1828507노트

반응식

HRID 1828507 반응식
[OH:1][C:2]1[N:3]=[C:4]2[CH:16]=[C:15]([CH2:17][CH2:18][C:19]3[S:20][CH:21]=[C:22]([CH:24]([CH3:26])[CH3:25])[N:23]=3)[CH:14]=[CH:13][N:5]2[C:6](=[O:12])[C:7]=1/[CH:8]=[CH:9]/[C:10]#[N:11].CN(C)C=O.C(N(C(C)C)CC)(C)C.I[CH2:42][CH:43]1[CH2:47][CH2:46][O:45][CH2:44]1>O.C(Cl)(Cl)Cl>[CH:24]([C:22]1[N:23]=[C:19]([CH2:18][CH2:17][C:15]2[CH:14]=[CH:13][N:5]3[C:6](=[O:12])[C:7](/[CH:8]=[CH:9]/[C:10]#[N:11])=[C:2]([O:1][CH2:42][CH:43]4[CH2:47][CH2:46][O:45][CH2:44]4)[N:3]=[C:4]3[CH:16]=2)[S:20][CH:21]=1)([CH3:26])[CH3:25]

참가 물질

7

반응물 4

HCID 6228DimethylformamideHCID 81531DiisopropylethylamineHCID 27630063-(Iodomethyl)oxolaneHCID 136347721(E)-2-{2-Hydroxy-8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-4-oxo-4H-pyrido-[1,2-a]pyrimidin-3-yl}-1-ethenylcyanide

생성물 1

HCID 22063773(E)-2-{8-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-4-oxo-2-(tetrahydro-3-furanylmethoxy)-4H-pyrido[1,2-a]pyrimidin-3-yl}-1-ethenylcyanide

시약·촉매·용매 2

HCID 962Water용매HCID 6212Chloroform용매

반응 조건

온도
80 °C

실험 절차

(E)-2-{2-Hydroxy-8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-4-oxo-4H-pyrido-[1,2-a]pyrimidin-3-yl}-1-ethenylcyanide (100 mg) was added with dimethylformamide (5 ml), diisopropylethylamine (500 ml) and 3-(iodomethyl)tetrahydrofuran (200 ml), and then the mixture was stirred at 80° C. for 2 hours and further stirred overnight at room temperature. After the reaction mixture was distributed between chloroform and water, the organic layer was dried over magnesium sulfate. After the solvent was evaporated under reduced pressure, the residue was purified by silica gel column chromatography to obtain the title compound (51 mg).

후처리

  1. stirringfurther stirred overnight at room temperature
  2. dry with materialthe organic layer was dried over magnesium sulfate
  3. customAfter the solvent was evaporated under reduced pressure
  4. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-2310b9414fe84d4495c05f6cc50a8793
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07056917B2

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