Carbon tetrabromide → HCID 22057750, 화합물

HRID 1828712노트

반응식

HRID 1828712 반응식
[CH2:1]([C:3]1[CH:8]=[C:7]([CH2:9]O)[CH:6]=[CH:5][C:4]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH3:2].C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C(Br)(Br)(Br)[Br:37]>C(Cl)Cl>[Br:37][CH2:9][C:7]1[CH:6]=[CH:5][C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:3]([CH2:1][CH3:2])[CH:8]=1

참가 물질

5

반응물 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 22057732HCID 22057732, 화합물

생성물 1

HCID 22057750HCID 22057750, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
0 °C

실험 절차

To a mixture of (2-ethyl-biphenyl-4-yl)-methanol (780 mg, 3.67 mmol) and PPh3 (1.44 g, 5.5 mmol) in DCM (15 mL) at 0° C. is added CBr4 (1.82 g, 5.5 mmol) in DCM (2 mL). The reaction is stirred at 0° C. for 1 h followed by concentration. The residue obtained is purified by silica gel chromatography (5% EtOAc in hexanes) to give 4-bromomethyl-2-ethyl-biphenyl as a colorless oil.

후처리

  1. concentrationfollowed by concentration
  2. customThe residue obtained
  3. customis purified by silica gel chromatography (5% EtOAc in hexanes)

출처 및 근거

ORD 기록
ord-5f2c0034743b4f15b6c39d70259ff01f
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07060697B2

반응 노트

불러오는 중…