Methyl Isocyanate → 1-Benzyl-4-piperidinyl Methylcarbamate

HRID 1829185

반응식

HRID 1829185 반응식
[CH3:1][N:2]=[C:3]=[O:4].[CH2:5]([N:12]1[CH2:17][CH2:16][CH:15]([OH:18])[CH2:14][CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C(Cl)(Cl)Cl>[CH3:1][NH:2][C:3](=[O:4])[O:18][CH:15]1[CH2:16][CH2:17][N:12]([CH2:5][C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:13][CH2:14]1

참가 물질

4

반응물 2

HCID 12228Methyl IsocyanateHCID 784611-Benzylpiperidin-4-ol

생성물 1

HCID 210299101-Benzyl-4-piperidinyl Methylcarbamate

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Methyl isocyanate (8.94 g, 157 mmol) was added to a solution of 1-benzyl-4-piperidinol (10 g, 52.3 mmol) in chloroform (80 ml), and the reaction stirred under reflux for 16 hours. The cooled mixture was concentrated under reduced pressure, the residual solid was triturated from 40–60 petroleum ether, and the product filtered and dried to afford the title compound as a white solid, 1 g. m.p.—106–108° C.

후처리

  1. temperatureunder reflux for 16 hours
  2. concentrationThe cooled mixture was concentrated under reduced pressure
  3. customthe residual solid was triturated from 40–60 petroleum ether
  4. filtrationthe product filtered
  5. customdried

출처 및 근거

ORD 기록
ord-514def51315f4b51927da02412393b9c
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07060836B2

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