Lithium hydroxide, monohydrate → 4-Hydroxy-1-methyl-1H-indole-2-carboxylic acid
반응식
[OH:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([C:12]([O:14]CC)=[O:13])[N:6]2[CH3:11].O[Li].O.OS([O-])(=O)=O.[K+]>C1COCC1.O>[OH:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([C:12]([OH:14])=[O:13])[N:6]2[CH3:11]참가 물질
6
실험 절차
To a solution of ethyl 4-hydroxy-1-methyl-1H-indole-2-carboxylate (0.20 g) in THF (20 mL) was added LiOH.H2O (0.1 g) in water (20 mL) and the resulting two phase solution was stirred at room temperature under nitrogen for 4 h. The reaction mixture was acidified with KHSO4 and the product was extracted into EtOAc, washed with brine, dried over MgSO4, and concentrated. The residue was chromatographed over silica gel with a mixture of EtOAc and hexane to give 0.12 g of the title compound. MS ES (M++H)=192.
후처리
- extractionthe product was extracted into EtOAc
- washwashed with brine
- dry with materialdried over MgSO4
- concentrationconcentrated
- customThe residue was chromatographed over silica gel with a mixture of EtOAc and hexane
출처 및 근거
- ORD 기록
- ord-7aa1c55655d84c6ca900f1f4497f5416
- 출처 데이터셋
- uspto-grants-2006_06
- 특허 번호
- US07064143B1
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