Water → 5-Fluoro-4-hydroxy-2-oxo-N-(propan-2-yl)pyrimidine-1(2H)-carboximidic acid

HRID 1834765노트

반응식

HRID 1834765 반응식
[F:1][C:2]1[C:3](=[O:9])[NH:4][C:5](=[O:8])[NH:6][CH:7]=1.[CH:10]([N:13]=[C:14]=[O:15])([CH3:12])[CH3:11].O>CS(C)=O>[F:1][C:2]1[C:3](=[O:9])[NH:4][C:5](=[O:8])[N:6]([C:14](=[O:15])[NH:13][CH:10]([CH3:12])[CH3:11])[CH:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 33855-FluorouracilHCID 61277Isopropyl isocyanate

생성물 1

HCID 1515285-Fluoro-4-hydroxy-2-oxo-N-(propan-2-yl)pyrimidine-1(2H)-carboximidic acid수율 68.5%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

13.0g (0.1 mole) of 5-fluorouracil was dissolved in 100ml of dimethyl sulfoxide, then 9.4g (0.11mole) of isopropyl isocyanate was added thereto at room temperature and stirred at the same temperature for 15 hours. The reaction mixture was poured into 800ml of water. The resultant precipitate was filtered off, washed with water and dried to give 14.7g (68.5% yield) of 5-fluoro-1-(iso-propylcarbamoyl)-uracil melting at 275°-285° C (decomposition).

후처리

  1. filtrationThe resultant precipitate was filtered off
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-b42e7e17a7614223987f4a7a6da207d7
출처 데이터셋
uspto-grants-1978_01
특허 번호
US04071519

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