Hydrochloric Acid → 5-(4-Fluorophenyl)thiophene-2-carboxylic acid

HRID 1835461노트

반응식

HRID 1835461 반응식
C[O:2][C:3]([C:5]1[S:6][C:7]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[CH:8][CH:9]=1)=[O:4].[OH-].[Na+].Cl>CO.O1CCCC1>[F:16][C:13]1[CH:12]=[CH:11][C:10]([C:7]2[S:6][C:5]([C:3]([OH:4])=[O:2])=[CH:9][CH:8]=2)=[CH:15][CH:14]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 3263823Methyl 5-(4-fluorophenyl)thiophene-2-carboxylate

생성물 1

HCID 18734015-(4-Fluorophenyl)thiophene-2-carboxylic acid수율 98.1%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
60 °C

실험 절차

To a solution of 2-methoxycarbonyl-5-(4-fluorophenyl)thiophene (1.15 g) in methanol (10 ml) and tetrahydrofuran (10 ml) was added an aqueous solution of sodium hydroxide (1N, 7.3 ml) followed by stirring at 60° C. for 3 hours. To the mixture was added hydrochloric acid (1N, 8 ml). The resulting precipitate was collected by filtration and dried to give 5-(4-fluorophenyl)thiophene-2-carboxylic acid (1.06 g, 98.1%).

후처리

  1. filtrationThe resulting precipitate was collected by filtration
  2. customdried

출처 및 근거

ORD 기록
ord-f568e23542fc4b08a5c5ad831d622aa7
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06770667B1

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