Hydrochloric Acid → 2-Methoxy-3-pyridineacetic acid

HRID 1837703노트

반응식

HRID 1837703 반응식
[CH3:1][O:2][C:3]1[C:8]([CH2:9][C:10]#N)=[CH:7][CH:6]=[CH:5][N:4]=1.[OH-:12].[Na+].Cl.C[OH:16]>>[CH3:1][O:2][C:3]1[C:8]([CH2:9][C:10]([OH:16])=[O:12])=[CH:7][CH:6]=[CH:5][N:4]=1

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 226785372-(2-Methoxypyridin-3-yl)acetonitrile

생성물 1

HCID 226783192-Methoxy-3-pyridineacetic acid

반응 조건

온도
100 °C

실험 절차

2.2 g of (2-methoxy-3-pyridyl)methyl cyanide, 35 ml of a 1N aqueous sodium hydroxide and 35 ml of methanol were stirred under heating at 100° C. for 1.5 hours. The mixture was cooled to room temperature, and then, 35 ml of a 5N aqueous hydrochloric acid was added thereto, and the solvent was evaporated. Ethanol was added to the residue and a solid was filtered off. Ethanol was evaporated, and ethanol was added again to the residue and a solid was filtered off. Ethanol was evaporated, to give 2.4 g of white crystals.

후처리

  1. temperatureThe mixture was cooled to room temperature
  2. customthe solvent was evaporated
  3. additionEthanol was added to the residue
  4. filtrationa solid was filtered off
  5. customEthanol was evaporated
  6. additionethanol was added again to the residue
  7. filtrationa solid was filtered off
  8. customEthanol was evaporated

출처 및 근거

ORD 기록
ord-35292d471e5d404ea43a0c9dea345650
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06784192B2

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