Benzene → 2,6-Dibenzoylpyridine

HRID 1841513

반응식

HRID 1841513 반응식
[Cl-].[Cl-].[Cl-].[Al+3].Cl[C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14](Cl)=[O:15])[N:9]=1)=[O:7].O.[CH:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14](=[O:15])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:9]=1)(=[O:7])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

5

반응물 4

HCID 241BenzeneHCID 962WaterHCID 773352,6-Pyridinedicarbonyl dichlorideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 3166562,6-Dibenzoylpyridine수율 58%

반응 조건

온도
60 °C

실험 절차

Aluminium trichloride (5.1 g, 3.18 mmol) was added to a suspension of 2,6-bis(chlorocarbonyl)pyridine (3.7 g, 18 mmol) in 200 ml of benzene. The reaction mixture was heated to 60° C. and kept at that temperature for 4 h and subsequently for 16 h at room temperature. The mixture was poured into water, the organic layer was separated and evaporated to dryness. The residue was dissolved in CH2Cl2 and filtered. Removal of CH2Cl2 in vacuum yielded 3.0 g (58%) of product.

후처리

  1. customthe organic layer was separated
  2. customevaporated to dryness
  3. dissolutionThe residue was dissolved in CH2Cl2
  4. filtrationfiltered
  5. customRemoval of CH2Cl2 in vacuum

출처 및 근거

ORD 기록
ord-48fbbee0fd4c4da082c56e3bc44acdc8
출처 데이터셋
uspto-grants-2004_01
특허 번호
US06683187B2

연결된 노트

불러오는 중…