Hydrochloric Acid → p-Bromomandelic acid

HRID 1841640노트

반응식

HRID 1841640 반응식
[OH-:1].[Na+].[Br:3][C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:14])[CH:11](Cl)Cl)=[CH:6][CH:5]=1.Cl.C([O:18]CC)C>O>[Br:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([OH:14])[C:11]([OH:18])=[O:1])=[CH:6][CH:5]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 14798Sodium HydroxideHCID 108908591-(4-Bromophenyl)-2,2-dichloroethan-1-one

생성물 1

HCID 97930p-Bromomandelic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Sodium hydroxide (72 g, 1.8 mol) is dissolved in 650 ml of water. The solution is heated to +60° C. and 1-(4-bromo-phenyl)-2,2-dichloro-ethanone (130 g, 0.48 mol) is added dropwise in order to control the reaction temperature not to exceed +65° C. After the addition is complete, stirring is continued for 1 hour at +60° C. The reaction mixture is then cooled to +15° C. and 95 ml of 10 N hydrochloric acid are added. Subsequently diethyl ether is added and the mixture is stirred vigorously for 30 minutes. The organic phase is separated and the aqueous layer is extracted twice with diethyl ether. The combined organic phases are washed with brine, dried over sodium sulfate and evaporated to yield (4-bromo-phenyl)-hydroxy-acetic acid. 1H-NMR (300 MHz, CDCl3): 4.95 (s, 1H, CHOH), 7.30 (d, 2H, CH arom.), 7.48 (d, 2H, CH arom.).

후처리

  1. temperatureThe solution is heated to +60° C.
  2. customto exceed +65° C
  3. additionAfter the addition
  4. temperatureThe reaction mixture is then cooled to +15° C.
  5. stirringthe mixture is stirred vigorously for 30 minutes
  6. customThe organic phase is separated
  7. extractionthe aqueous layer is extracted twice with diethyl ether
  8. washThe combined organic phases are washed with brine
  9. dry with materialdried over sodium sulfate
  10. customevaporated

출처 및 근거

ORD 기록
ord-5dcff7c2c80a438181359f7d149ca8f9
출처 데이터셋
uspto-grants-2004_01
특허 번호
US06683211B1

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