Acryloyl chloride → N-[4-(2-Morpholin-4-yl-ethylsulfamoyl)-phenyl]-acrylamide

HRID 1841952

반응식

HRID 1841952 반응식
C(N(C(C)C)CC)(C)C.[NH2:10][C:11]1[CH:16]=[CH:15][C:14]([S:17]([NH:20][CH2:21][CH2:22][N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)(=[O:19])=[O:18])=[CH:13][CH:12]=1.[C:29](Cl)(=[O:32])[CH:30]=[CH2:31]>C1COCC1>[N:23]1([CH2:22][CH2:21][NH:20][S:17]([C:14]2[CH:13]=[CH:12][C:11]([NH:10][C:29](=[O:32])[CH:30]=[CH2:31])=[CH:16][CH:15]=2)(=[O:19])=[O:18])[CH2:24][CH2:25][O:26][CH2:27][CH2:28]1

참가 물질

5

반응물 3

HCID 13140Acryloyl chlorideHCID 81531DiisopropylethylamineHCID 120569Benzenesulfonamide, 4-amino-N-[2-(4-morpholinyl)ethyl]-

생성물 1

HCID 67194942N-[4-(2-Morpholin-4-yl-ethylsulfamoyl)-phenyl]-acrylamide수율 5.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Diisopropylethylamine (0.09 ml, 0.5 mmol) was added in one portion to a stirred solution of 4-amino-N-(2-morpholin-4-yl-ethyl)-benzenesulfonamide (0.1 g, 0.35 mmol) in THF (3 ml) at room temperature. To this mixture was added acryloyl chloride (0.03 ml, 0.38 mmol) in one portion and the mixture was stirred at room temperature under a nitrogen atmosphere for 1 hour. After this time, the mixture was concentrated under vacuum and the resulting residue purified by Prep HPLC to give the title compound (6 mg, 5% yield) as a white solid.

후처리

  1. concentrationAfter this time, the mixture was concentrated under vacuum
  2. customthe resulting residue purified by Prep HPLC

출처 및 근거

ORD 기록
ord-fbc6602e838844ea8049e8f1cc4695df
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946197B2

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