Diisopropylethylamine → N-(2-chloro-4-hydroxy-6-nitrophenyl)tetrahydrofuran-3-carboxamide

HRID 1846490

반응식

HRID 1846490 반응식
[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([OH:11])=[CH:4][C:3]=1[Cl:12].CCN(C(C)C)C(C)C.[O:22]1[CH2:26][CH2:25][CH:24]([C:27](Cl)=[O:28])[CH2:23]1>C(Cl)Cl>[Cl:12][C:3]1[CH:4]=[C:5]([OH:11])[CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=1[NH:1][C:27]([CH:24]1[CH2:25][CH2:26][O:22][CH2:23]1)=[O:28]

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 14020412Tetrahydrofuran-3-carbonyl chloride2회HCID 669783384-Amino-3-chloro-5-nitrophenol

생성물 1

HCID 66978219N-(2-chloro-4-hydroxy-6-nitrophenyl)tetrahydrofuran-3-carboxamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

0.40 g (2.12 mmol) 4-amino-3-chloro-5-nitrophenol were placed in 5 mL DCM. 0.44 mL DIPEA and 0.34 g tetrahydrofuran-3-carbonyl chloride were added and the mixture was stirred for 2 h at RT. A further 0.34 g tetrahydrofuran-3-carbonyl chloride was added and the mixture was stirred overnight at RT. The reaction mixture was diluted with DCM and washed with water. The organic phase was evaporated down i.vac.

후처리

  1. stirringthe mixture was stirred overnight at RT
  2. washwashed with water
  3. customThe organic phase was evaporated down i.vac

출처 및 근거

ORD 기록
ord-750612a2b2be49fea853381032bdd2ab
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952014B2

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