1-Hydroxybenzotriazole → HCID 57901813, 화합물

HRID 1851428노트

반응식

HRID 1851428 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[S:6]([NH:9][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:18]=1[NH:17][C:16]([C:19]([OH:21])=O)=[CH:15]2)(=[O:8])=[O:7].Br.[Br:23][CH2:24][CH2:25][NH2:26].N1(O)C2C=CC=CC=2N=N1.Cl.CN(C)CCCN=C=NCC>O.CN(C)C=O.C(N(CC)CC)C>[Br:23][CH2:24][CH2:25][NH:26][C:19]([C:16]1[NH:17][C:18]2[C:14]([CH:15]=1)=[CH:13][CH:12]=[CH:11][C:10]=2[NH:9][S:6]([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)(=[O:7])=[O:8])=[O:21]

참가 물질

8

반응물 4

HCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 27742172-Bromoethylamine hydrobromideHCID 57476168HCID 57476168, 화합물

생성물 1

HCID 57901813HCID 57901813, 화합물수율 37.6%

시약·촉매·용매 3

HCID 962Water용매HCID 6228Dimethylformamide용매HCID 8471Triethylamine용매

실험 절차

To a mixture of 7-[(2-thienylsulfonyl)amino]-1H-indole-2-carboxylic acid (0.70 g), (2-bromoethyl)amine hydrobromide (0.49 g), 1H-1,2,3-benzotriazol-1-ol (0.32 g), triethylamine (0.34 mL) and N,N-dimethylformamide (20 mL) was added N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride (0.46 g) at 0° C., and the mixture was stirred at room temperature overnight. Water was added to the reaction mixture, and the obtained crystals were filtrated, washed with water and dried to give the title compound (0.35 g, 37%) as colorless crystals. melting point 218-219° C. (decomposition).

후처리

  1. filtrationthe obtained crystals were filtrated
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-92f51ad10fa34136a28bc8698b665246
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08957070B2

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