Acetyl chloride → 1-(4-Chloro-2-fluoro-5-methylphenyl)ethanone

HRID 1857968노트

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HRID 1857968 반응식
[C:1](Cl)(=[O:3])[CH3:2].[Cl:5][C:6]1[CH:11]=[C:10]([F:12])[CH:9]=[CH:8][C:7]=1[CH3:13].[Cl-].[Al+3].[Cl-].[Cl-]>Cl>[CH3:13][C:7]1[CH:8]=[C:9]([C:1]([CH3:2])=[O:3])[C:10]([F:12])=[CH:11][C:6]=1[Cl:5]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 967472-Chloro-4-fluorotolueneHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 27365641-(4-Chloro-2-fluoro-5-methylphenyl)ethanone

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

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온도
120 °C

실험 절차

At 60° C., 157 g of acetyl chloride were added dropwise to a mixture of 250 g of 2-chloro-4-fluorotoluene and 267 g of aluminum chloride. The reaction mixture was stirred at 120° C. for 2 hours and then, while still at 100° C., poured onto 2 l of an ice/water mixture. 180 ml of concentrated hydrochloric acid were subsequently stirred into the resulting mixture. The product was then extracted using three times 200 ml of dichloromethane. The organic phase was then washed with 200 ml of water, dried over sodium sulfate and finally concentrated. Yield: 290 g; oil.

후처리

  1. extractionThe product was then extracted
  2. washThe organic phase was then washed with 200 ml of water
  3. dry with materialdried over sodium sulfate
  4. concentrationfinally concentrated

출처 및 근거

ORD 기록
ord-56e843515cb84acab58e1c2333dc5328
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06150303

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