Ammonia → 2-{4-[2-(4-Fluoro-phenoxy)-ethoxy]-3-methoxy-phenyl}-ethylamine

HRID 1862498

반응식

HRID 1862498 반응식
[F:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]#[N:18])=[CH:12][C:11]=2[O:19][CH3:20])=[CH:4][CH:3]=1.N>O1CCCC1.[Ni]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][NH2:18])=[CH:12][C:11]=2[O:19][CH3:20])=[CH:21][CH:22]=1

참가 물질

5

반응물 2

HCID 222AmmoniaHCID 18619854{4-[2-(4-Fluoro-phenoxy)-ethoxy]-3-methoxy-phenyl}-acetonitrile

생성물 1

HCID 186198302-{4-[2-(4-Fluoro-phenoxy)-ethoxy]-3-methoxy-phenyl}-ethylamine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of {4-[2-(4-fluoro-phenoxy)-ethoxy]-3-methoxy-phenyl}-acetonitrile (14.8 g), liquid ammonia (8.4 g) and Raney-nickel (4.5 g) in tetrahydrofuran (120 ml) is shaken in an autoclave under hydrogen (130 bar) at +60° C. for 2 hours. The reaction mixture is filtered and evaporated. 2-{4-[2-(4-Fluoro-phenoxy)-ethoxy]-3-methoxy-phenyl}-ethylamine is obtained as an oil.

후처리

  1. filtrationThe reaction mixture is filtered
  2. customevaporated

출처 및 근거

ORD 기록
ord-d70083d22771496486db7af597fc32f4
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06538016B2

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