M-Cresol → HCID 178433662, 화합물
반응식
Cl.Cl.[CH3:3][C:4]1[NH:8][CH:7]=[N:6][C:5]=1[CH2:9][CH2:10][NH2:11].[OH-].[Na+].C1(C)C=CC=C(O[C:21](=[NH:25])[NH:22][C:23]#[N:24])C=1.C1C(O)=CC=CC=1C>C(O)(C)C>[C:21]([NH:22][C:23]([NH:11][CH2:10][CH2:9][C:5]1[N:6]=[CH:7][NH:8][C:4]=1[CH3:3])=[NH:24])#[N:25]참가 물질
6
실험 절차
4.94 g. (0.249 mole) 5-methyl-4-(2-aminoethyl) imidazole dihydrochloride is converted to the free base with NaOH. The free base is combined with 4.36 g. (0.0249 mole) of O-m-tolyl-N-cyanoisourea in 63 ml. isopropanol. This mixture is refluxed for one hour. The mixture is then cooled to room temperature, filtered to remove insoluble material, and the solvent is evaporated to obtain a cloudy oil of the product mixed with m-cresol.
후처리
- temperatureThis mixture is refluxed for one hour
- filtrationfiltered
- customto remove insoluble material
- customthe solvent is evaporated
- customto obtain a cloudy oil of the product
출처 및 근거
- ORD 기록
- ord-e42112a5cade4e968931eb96eaf9b353
- 출처 데이터셋
- uspto-grants-1979_09
- 특허 번호
- US04166860
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