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Dimethyl Sulfoxide → 2-Cyano-2-(4-phenylthiophenyl)hexyl bromide

HRID 1862999
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HRID 1862999 반응식
[C:1]1([S:7][C:8]2[CH:13]=[CH:12][C:11]([CH:14]([CH2:17][CH2:18][CH2:19][CH3:20])[C:15]#[N:16])=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:21][CH2:22]Br.CS(C)=O.[OH-].[Na+]>O>[C:15]([C:14]([C:11]1[CH:12]=[CH:13][C:8]([S:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:9][CH:10]=1)([CH2:17][CH2:18][CH2:19][CH3:20])[CH2:22][Br:21])#[N:16]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 679Dimethyl SulfoxideHCID 3024DibromomethaneHCID 14798Sodium HydroxideHCID 544229802-(4-Phenylthiophenyl) hexanenitrile

생성물 1

HCID 542149592-Cyano-2-(4-phenylthiophenyl)hexyl bromide수율 101.5%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a mixture of 31 g (0.1 mole) of 2-(4-phenylthiophenyl) hexanenitrile, 22 g (0.13 mole) of dibromomethane and 100 ml of dimethyl sulfoxide is added 12 g (0.15 mole) of 50% sodium hydroxide solution dropwise with stirring. Reaction mixture is stirred at 60° for 1/2 hour and then poured into water and extracted with ether. The combined ether extracts are washed with water and dried over MgSO4. Solvent is evaporated to give 38 g of product.

후처리

  1. customReaction mixture
  2. stirringis stirred at 60° for 1/2 hour
  3. extractionextracted with ether
  4. washThe combined ether extracts are washed with water
  5. dry with materialdried over MgSO4
  6. customSolvent is evaporated

출처 및 근거

ORD 기록
ord-14fbbb3e96d449d5b8370468467e0b7a
출처 데이터셋
uspto-grants-1979_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04167576

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