Hydrochloric Acid → HCID 66973439, 화합물
반응식
[O:1]=[C:2]1[CH2:7][O:6][C@H:5]2[CH2:8][C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=3[C@H:4]2[N:3]1[CH2:15][C:16]([O:18]CC)=[O:17].[Li+].[OH-].Cl>C1COCC1.O>[O:1]=[C:2]1[CH2:7][O:6][C@H:5]2[CH2:8][C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=3[C@H:4]2[N:3]1[CH2:15][C:16]([OH:18])=[O:17]참가 물질
6
실험 절차
To a solution of ethyl [(4aR,9aS)-3-oxo-2,3,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-4(4aH)-yl]acetate from Step C (480 mg, 1.74 mmol) in THF (7.5 mL) and H2O (2.5 mL) was added 1 N aqueous LiOH (2.1 mL, 2.09 mmol) and the resulting mixture was stirred at ambient temperature for 4 h. The mixture was adjusted to pH 4 by addition of 1 N HCl and concentrated to dryness in vacuo to give the title compound. MS: m/z=248 (M+1).
후처리
- concentrationconcentrated to dryness in vacuo
출처 및 근거
- ORD 기록
- ord-a4a1cbf934d24bbaa5a5172e4d35f03e
- 출처 데이터셋
- uspto-grants-2009_12
- 특허 번호
- US07629338B2
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