1,1-Dichloroethane → 1-(3-Chloropyridin-2-yl)piperazine

HRID 1868010

반응식

HRID 1868010 반응식
[Cl:1][C:2]1[C:3]([N:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.C(O)(C(F)(F)F)=O.ClC(Cl)C>ClCCl>[Cl:1][C:2]1[C:3]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)=[N:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 63651,1-DichloroethaneHCID 6422Trifluoroacetic acid2회HCID 11630777Tert-butyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate

생성물 1

HCID 114129441-(3-Chloropyridin-2-yl)piperazine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a clear solution of tert-butyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate in anhydrous dichloromethane (25 mL) was added TFA (25 mL) dropwise. The yellow solution was stirred at room temperature for 2.5 hour. Reaction was complete as determined by TLC. TFA was azeotropped with dichloroethane to give 1-(3-chloropyridin-2-yl)piperazine in quantitative yield (1.265 g).

후처리

  1. customReaction

출처 및 근거

ORD 기록
ord-30b29d4f567642f38fcd9d67ddf87c72
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07632838B2

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