Potassium Hydroxide → 2-methyl-8H-indeno[2,1-b]thiophene
반응식
[CH3:1][C:2]1[S:6][C:5]2[C:7](=O)[C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[C:4]=2[CH:3]=1.O.NN.[OH-].[K+]>C(O)COCCO.O>[CH3:1][C:2]1[S:6][C:5]2[CH2:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[C:4]=2[CH:3]=1참가 물질
6
반응 조건
- 온도
- 80 °C
실험 절차
A mixture of 6.83 g (0.034 mol) of 2-methyl-8H-indeno[2,1-b]thiophen-8-one and 9.1 mL (0.182 mol) of hydrazine monohydrate in 91 mL of diethylene glycol was stirred at 80° C. for 40 min and then refluxed for 1 h. The resulting mixture was cooled to room temperature, treated with a solution of 9.5 g (0.169 mol) of KOH in 34 mL water and then refluxed for 2 h. The resulting mixture was poured into 600 mL of water, the precipitate was filtered, washed 5 times with 200 mL of water and dried. Yield 5.8 g (92%).
후처리
- temperaturerefluxed for 1 h
- temperatureThe resulting mixture was cooled to room temperature
- temperaturerefluxed for 2 h
- filtrationthe precipitate was filtered
- washwashed 5 times with 200 mL of water
- customdried
출처 및 근거
- ORD 기록
- ord-7330e21cf03146989d0f1f7327e1c232
- 출처 데이터셋
- uspto-grants-2009_12
- 특허 번호
- US07635781B2
반응 노트
불러오는 중…