Potassium Carbonate → (2-Methyl-imidazol-1-yl)-acetic acid methyl ester

HRID 18689

반응식

HRID 18689 반응식
[CH3:1][O:2][C:3](=[O:6])[CH2:4]Br.[CH3:7][C:8]1[NH:9][CH:10]=[CH:11][N:12]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:1][O:2][C:3](=[O:6])[CH2:4][N:9]1[CH:10]=[CH:11][N:12]=[C:8]1[CH3:7]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 127492-MethylimidazoleHCID 60984Methyl bromoacetate

생성물 1

HCID 28940036(2-Methyl-imidazol-1-yl)-acetic acid methyl ester수율 47%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

4 ml of bromo acetic acid methyl ester is dissolved in 30 ml DMF and 5.2 g of 2-methylimidazole and 11.2 g potassium carbonate are added. The reaction mixture is stirred at room temperature for several hours and then subjected to aqueous work up. After removal of the solvent the pure product is obtained by flash chromatography in 47 to 78% yield.

후처리

  1. customAfter removal of the solvent the pure product
  2. customis obtained by flash chromatography in 47 to 78% yield

출처 및 근거

ORD 기록
ord-0bedc00b6d0b4bcbacdd64180013cb6f
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741488B2

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