Potassium Carbonate → (2-Methyl-imidazol-1-yl)-acetic acid methyl ester
반응식
[CH3:1][O:2][C:3](=[O:6])[CH2:4]Br.[CH3:7][C:8]1[NH:9][CH:10]=[CH:11][N:12]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:1][O:2][C:3](=[O:6])[CH2:4][N:9]1[CH:10]=[CH:11][N:12]=[C:8]1[CH3:7]참가 물질
5
실험 절차
4 ml of bromo acetic acid methyl ester is dissolved in 30 ml DMF and 5.2 g of 2-methylimidazole and 11.2 g potassium carbonate are added. The reaction mixture is stirred at room temperature for several hours and then subjected to aqueous work up. After removal of the solvent the pure product is obtained by flash chromatography in 47 to 78% yield.
후처리
- customAfter removal of the solvent the pure product
- customis obtained by flash chromatography in 47 to 78% yield
출처 및 근거
- ORD 기록
- ord-0bedc00b6d0b4bcbacdd64180013cb6f
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07741488B2
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