Hydrochloric Acid → HCID 66916241, 화합물

HRID 1873695노트

반응식

HRID 1873695 반응식
[NH2:1][C:2]1[CH:24]=[CH:23][C:5]([O:6][C:7]2[C:16]3[C:11](=[CH:12][C:13]([O:21][CH3:22])=[C:14]([C:17]([O:19]C)=[O:18])[CH:15]=3)[N:10]=[CH:9][CH:8]=2)=[C:4]([F:25])[CH:3]=1.CO.[OH-].[Na+].Cl>O>[NH2:1][C:2]1[CH:24]=[CH:23][C:5]([O:6][C:7]2[C:16]3[C:11](=[CH:12][C:13]([O:21][CH3:22])=[C:14]([C:17]([OH:19])=[O:18])[CH:15]=3)[N:10]=[CH:9][CH:8]=2)=[C:4]([F:25])[CH:3]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 66916282Methyl 4-(4-amino-2-fluorophenoxy)-7-methoxyquinoline-6-carboxylate

생성물 1

HCID 66916241HCID 66916241, 화합물수율 90%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Compound 39b (1.0 g) was added to methanol (10 mL), and 4M aqueous sodium hydroxide (650 μL) and water (400 μL) were further added thereto, followed by stirring at room temperature for 2 hours. After completion of reaction, 6N aqueous hydrochloric acid was added to the reaction mixture, to thereby adjust the pH to 3, and the precipitate was filtrated, whereby compound 39c was yielded (862 mg, yield: 90%).

후처리

  1. additionwere further added
  2. additionwas added to the reaction mixture
  3. filtrationthe precipitate was filtrated

출처 및 근거

ORD 기록
ord-d7d62e3529aa402381a804b121bcb24f
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08304427B2

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