Hydrochloric Acid → 1-Benzyl-4-methylpyrrolidine-3-carboxylic acid

HRID 1875332노트

반응식

HRID 1875332 반응식
[CH2:1]([N:8]1[CH2:12][CH:11]([CH3:13])[CH:10]([C:14]([O:16]C)=[O:15])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C([O-])=O.[OH-].[Li+].Cl>CO>[CH2:1]([N:8]1[CH2:12][CH:11]([CH3:13])[CH:10]([C:14]([OH:16])=[O:15])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 84468TrifluoroacetateHCID 3638244Methyl 1-benzyl-4-methylpyrrolidine-3-carboxylate

생성물 1

HCID 50457831-Benzyl-4-methylpyrrolidine-3-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2.0 g (5.7 mmol) methyl (3RS,4RS)-1-benzyl-4-methyl-pyrrolidine-3-carboxylate (as the trifluoroacetate salt) are dissolved in 4 ml of methanol and combined with 5 ml lithium hydroxide solution (8% in water). The mixture is stirred for five hours at RT, then mixed with 3.2 ml 4N hydrochloric acid and evaporated to dryness.

후처리

  1. customevaporated to dryness

출처 및 근거

ORD 기록
ord-dac14bd459c04ddeb6335f0b24db07f8
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08309542B2

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