Hydrochloric Acid → (2,5-Dimethylfuran-3-yl)methanol

HRID 1877044

반응식

HRID 1877044 반응식
[CH3:1][C:2]1[O:3][C:4]([CH3:10])=[CH:5][C:6]=1[C:7](Cl)=[O:8].[BH4-].[Na+].Cl.O>O1CCCC1>[CH3:1][C:2]1[O:3][C:4]([CH3:10])=[CH:5][C:6]=1[CH2:7][OH:8]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 27348042,5-Dimethyl-3-furoyl ChlorideHCID 4311764Sodium borohydride

생성물 1

HCID 10396847(2,5-Dimethylfuran-3-yl)methanol수율 100%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
0 °C

실험 절차

A solution of 2,5-dimethylfuran-3-carbonyl chloride (5.0 g) in tetrahydrofuran (20 mL) was added dropwise to a suspension of sodium borohydride (3.4 g) in tetrahydrofuran (50 mL) at 0° C. and, after the completion of the dropwise addition, the mixture was stirred at 0° C. for 1 hr. The reaction mixture was treated with 1N hydrochloric acid, poured into water, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over magnesium sulfate. The solvent was evaporated under reduced pressure to give the title compound (3.8 g, 100%) as an oil.

후처리

  1. additionafter the completion of the dropwise addition
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with saturated brine
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-ec82b427591b410b992cbafd1a71bb53
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08309580B2

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